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Intriguingly, when using the same probes ex vivo in Ussing chambers, the difference is much less pronounced with a LMR of ~0.8 ex vivo vs

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Obtaining unlicensed or compounded versions outside a trial is not recommended

34 Unfortunately, we lacked systematic access to glycated haemoglobin values, which could have indicated that cases in our study population were with well-managed diabetes inadvertently selected leading to a rate of birth defects similar to the general population